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Fast-acting bronchodilators include albuterol (Ventolin, Proventil), bitolterol (Tornalate), metaproterenol (Alupent), and pirbuterol (Maxair). Therefore, Ventolin HFA, like all other sympathomimetic amines, should be used with caution in patients with underlying cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias, and hypertension. The data from pediatric patients are based upon 1 clinical trial in which 46 patients with asthma 4 to 11 years of age were treated with Ventolin HFA 2 inhalations 4 times daily for 2 weeks’ duration. Because of the potential for tumorigenicity shown for albuterol in animal studies and lack of experience with the use of Ventolin HFA by nursing mothers, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Over the 4-week treatment period, there were no treatment differences in asthma symptom scores between the groups receiving Ventolin HFA 90 mcg, Ventolin HFA 180 mcg, and placebo in either study. Ventolin HFA should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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